What to Know About Ketamine Therapy for Depression

 

Ketamine remains a fairly new player on the field of depression treatment. Here’s a quick snapshot of its history:

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Healthcare professionals first began using ketamine as an anesthetic in the 1960sTrusted Source. Before long, they noticed it didn’t just cause a sedative effect. Some people also reported improvements in their mood after receiving ketamine, says Kyle Keller, LICSW, a CIIS-certified psychedelic-assisted psychotherapist in Minnesota and founder of Intero Psychedelic Therapy.

During the 2000sTrusted Source, medical professionals began researching ketamine as a possible treatment for depression, according to Hans Eriksson, a clinical psychiatrist and chief medical officer at HMNC Brain Health.

In 2019Trusted Source, the Food and Drug Administration (FDA) approved the use of an esketamine nasal spray called Spravato for treatment-resistant depression. Esketamine is a more potent form of ketamine, so doctors can prescribe it at lower doses that have a similar effect.

Treatment-resistant depression refers to depression symptoms that don’t respond to two or more types of antidepressant medication. Estimates suggest up to 30% of peopleTrusted Source with major depression have treatment-resistant depression.

Antidepressants aren’t the only treatment option for depression symptoms, of course. You may have also tried:

psychotherapy

hypnotherapy

meditation

acupuncture

These approaches don’t always relieve severe depression symptoms, including thoughts of suicide — and that’s where ketamine could make a difference.

Below, get the details on the potential benefits and risks of trying ketamine for treatment-resistant depression, plus guidance on getting a prescription from a qualified mental health professional.